SB431542, 200MG 12722-Sterile The leukocyte integrins are a

The leukocyte integrins are a family of heterodimeric receptors that mediatedivalent cation-dependent cellular adhesion reactions

since it has cyanopropyl group of medium polarity chemically bonded to the stationary phase

Upon binding

It is supplied in a unit of 25 mg and should be stored at an ambient temperature of greater than 5 °C

SB431542, 200MG 12722-Sterile The leukocyte integrins are aSB431542 is a potent and selective inhibitor of the TGF superfamily type 1 (TGF 1) activin receptor like kinase (ALK5) receptors and its relatives ALK4 and ALK7. It does not affect the BMP receptors ALK2 ALK3 ALK6. SB431542 inhibits the TGF mediated activation of SMAD proteins expression of collagen and fibronectin cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK p38 or JNK.